Genetic Programming Theory and Practice VI was developed from the sixth workshop at the University of Michigan’s Center for the Study of Complex Systems to facilitate the exchange of ideas and information related to the rapidly advancing field of Genetic Programming (GP). Contributions from the foremost international researchers and practitioners in the GP arena examine the similarities and differences between theoretical and empirical results on real-world problems. The text explores the synergy between theory and practice, producing a comprehensive view of the state of the art in GP application. These contributions address several significant interdependent themes which emerged from this year’s workshop, including: (1) Making efficient and effective use of test data. (2) Sustaining the long-term evolvability of our GP systems. (3) Exploiting discovered subsolutions for reuse. (4) Increasing the role of a Domain Expert.